Fact Check: The vagus nerve controls anxiety

Fact Check: The vagus nerve controls anxiety

Published July 15, 2025
±
VERDICT
Partially True

# Fact Check: "The vagus nerve controls anxiety" ## What We Know The vagus nerve is a critical component of the parasympathetic nervous system, which...

Fact Check: "The vagus nerve controls anxiety"

What We Know

The vagus nerve is a critical component of the parasympathetic nervous system, which regulates various bodily functions, including mood and anxiety responses. Research indicates that the vagus nerve plays a role in modulating anxiety through its connections between the brain and the gastrointestinal tract, often referred to as the "brain-gut axis" (Breit et al.). Studies have shown that vagus nerve stimulation (VNS) can reduce anxiety symptoms in both preclinical models and human trials. For instance, VNS has been explored as a treatment for anxiety disorders, particularly in individuals with autism spectrum disorder (ASD), where it may enhance the effectiveness of cognitive behavioral therapy (Shivaswamy et al.).

Furthermore, the vagus nerve's activity is linked to the regulation of stress responses, with increased vagal tone associated with resilience against anxiety and mood disorders (Breit et al.). This suggests that while the vagus nerve does not directly "control" anxiety, it significantly influences the physiological and psychological mechanisms underlying anxiety responses.

Analysis

The claim that "the vagus nerve controls anxiety" is somewhat misleading. While the vagus nerve does play a crucial role in modulating anxiety through its influence on the brain and body, it does not exert direct control over anxiety levels. The evidence supporting the vagus nerve's role in anxiety modulation comes from various studies, including those that demonstrate VNS's potential to reduce anxiety symptoms and enhance the efficacy of therapeutic interventions (Shivaswamy et al., Breit et al.).

However, the interpretation of these findings must be approached with caution. Many studies focus on specific populations, such as individuals with ASD, and the results may not be universally applicable to all anxiety disorders. Additionally, while VNS shows promise, it is still considered an adjunctive treatment rather than a standalone solution for anxiety management (Shivaswamy et al.).

The reliability of the sources used in this analysis is generally high, as they are peer-reviewed articles published in reputable journals. However, the complexity of the vagus nerve's role in anxiety suggests that further research is needed to fully understand its mechanisms and implications for treatment.

Conclusion

Verdict: Partially True

The statement that "the vagus nerve controls anxiety" is partially true but oversimplifies the relationship. The vagus nerve does influence anxiety through its role in the parasympathetic nervous system and its interactions with brain regions involved in emotional regulation. However, it does not directly control anxiety levels. The vagus nerve's modulation of anxiety is supported by research, particularly in specific contexts such as VNS therapy, but it is not a definitive controller of anxiety.

Sources

  1. Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder
  2. Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders
  3. Vagus nerve stimulation and mental health
  4. Stress-induced vagal activity influences anxiety-relevant behavior
  5. Reduction of Anxiety-Related Symptoms Using Low-Intensity Focused Ultrasound
  6. Bolster Your Brain by Stimulating the Vagus Nerve
  7. Effect of vagus nerve stimulation (taVNS) on anxiety and sleep problems
  8. Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders

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Fact Check: drug widely used to treat nerve pain has been linked with dementia and cognitive impairment. A new study analyzing over 26,000 patient records has found a significant link between long-term gabapentin use and increased risk of both dementia and mild cognitive impairment (MCI). Patients with six or more prescriptions were 29% more likely to be diagnosed with dementia and 85% more likely to develop MCI within a decade. The risk was even greater among adults aged 35 to 49, prompting researchers to urge physicians to monitor cognitive health in patients using the drug long-term. Gabapentin has grown in popularity as a less addictive alternative to opioids. However, its mechanism—dampening communication between neurons—may also disrupt critical brain connections, potentially contributing to cognitive decline. While past research has been inconclusive, this new study’s large sample size offers more weight to the growing concerns. Researchers stress the importance of further investigation to determine whether gabapentin plays a causal role in dementia development or simply correlates with other risk factors in chronic pain patients. Source: Regional Anesthesia & Pain Medicine (2025).

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Fact Check:  drug widely used to treat nerve pain has been linked with dementia and cognitive impairment.
A new study analyzing over 26,000 patient records has found a significant link between long-term gabapentin use and increased risk of both dementia and mild cognitive impairment (MCI). 
Patients with six or more prescriptions were 29% more likely to be diagnosed with dementia and 85% more likely to develop MCI within a decade. 
The risk was even greater among adults aged 35 to 49, prompting researchers to urge physicians to monitor cognitive health in patients using the drug long-term.
Gabapentin has grown in popularity as a less addictive alternative to opioids. However, its mechanism—dampening communication between neurons—may also disrupt critical brain connections, potentially contributing to cognitive decline. 
While past research has been inconclusive, this new study’s large sample size offers more weight to the growing concerns. Researchers stress the importance of further investigation to determine whether gabapentin plays a causal role in dementia development or simply correlates with other risk factors in chronic pain patients.
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