Fact Check: Some men can be born unable to make estrogen and some women can be born unable to make testosterone

Fact Check: Some men can be born unable to make estrogen and some women can be born unable to make testosterone

Published August 24, 2025
VERDICT
True

# Fact-Check Article: "Some men can be born unable to make estrogen and some women can be born unable to make testosterone" ## What We Know The claim...

Fact-Check Article: "Some men can be born unable to make estrogen and some women can be born unable to make testosterone"

What We Know

The claim that "some men can be born unable to make estrogen and some women can be born unable to make testosterone" is supported by medical literature on specific genetic conditions.

  1. Aromatase Deficiency: This condition results in reduced levels of estrogen due to a deficiency in the aromatase enzyme, which converts androgens (like testosterone) into estrogens. Individuals affected by this condition can be genetically male (XY) but may have issues with estrogen production, leading to various developmental and health issues (MedlinePlus Genetics).

  2. Androgen Insensitivity Syndrome (AIS): This genetic condition affects individuals who are genetically male (XY) but are unable to respond to androgens, including testosterone. There are different forms of AIS, including complete androgen insensitivity syndrome, where individuals develop female external characteristics despite having male internal organs. This condition illustrates that some individuals can be born with a lack of response to testosterone, leading to a female phenotype (NHS, Cleveland Clinic).

  3. Hormonal Development: Hormones play a critical role in sexual differentiation during prenatal development. Testosterone is crucial for male development, while estrogen is important for female development. Disruptions in hormone production or receptor function can lead to conditions where individuals may not produce or respond to these hormones appropriately (Hines, 2011).

Analysis

The evidence supports the claim that some men can be born unable to make estrogen and some women can be born unable to make testosterone.

  • Aromatase Deficiency: The condition is well-documented and recognized in medical literature. It specifically affects estrogen production, confirming that some genetically male individuals can indeed have impaired estrogen synthesis (MedlinePlus Genetics). This source is reliable as it is a government health resource.

  • Androgen Insensitivity Syndrome: This syndrome is a well-established medical condition that affects sexual development. The inability to respond to testosterone leads to the development of female characteristics in genetically male individuals. This is corroborated by multiple medical sources, including the NHS and the Cleveland Clinic, both of which are reputable health organizations.

  • Source Reliability: The sources used in this analysis are credible and come from established medical institutions and peer-reviewed research. The study by Hines (2011) is particularly relevant as it discusses the role of hormones in sexual differentiation and orientation, providing a broader context for understanding how hormonal deficiencies can occur (Hines, 2011).

Conclusion

Verdict: True
The claim that "some men can be born unable to make estrogen and some women can be born unable to make testosterone" is true based on documented medical conditions such as aromatase deficiency and androgen insensitivity syndrome. These conditions illustrate that hormonal production and response can be impaired, leading to significant variations in sexual development.

Sources

  1. Prenatal endocrine influences on sexual orientation and ...
  2. Androgen insensitivity syndrome - Genetics
  3. Aromatase deficiency: MedlinePlus Genetics
  4. Androgen Insensitivity Syndrome
  5. Androgen insensitivity syndrome - Causes
  6. Androgen Insensitivity Syndrome (AIS): Types & Symptoms
  7. Androgen insensitivity
  8. Androgen insensitivity syndrome

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That history lingers most clearly at the Mound City National Cemetery, just beyond the edge of town. I wasn’t expecting to find it, and I certainly wasn’t expecting the names etched into some of the stones. Two men in particular stood out, John Basil Turchin and Alexander Bielaski. Both born in the Russian Empire. Both connected to Abraham Lincoln. Both now buried here, far from where they began.

John Basil Turchin (born Ivan Turchaninov) had once been a colonel in the Russian Imperial Army. He fought in the Crimean War before immigrating to the United States in 1856. When the Civil War broke out, he offered his experience to the Union cause with fierce conviction. His military background and abolitionist ideals caught Lincoln’s attention, and he was appointed a brigadier general, becoming the only Russian born general to serve in the Union Army. He died in 1901 and was laid to rest here, among the soldiers he once led, and some that he fought against.
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Fact Check: Built on ancient Native American mounds near the meeting point of where the Ohio and Mississippi Rivers clash, the town sits at a natural crossroads. During the Civil War, that geography turned it into a vital Union stronghold. Mound City became home to one of the largest military hospitals in the West and served as a major naval station. Soldiers from both sides passed through some to recover, many not. It may be quiet now, but this place once pulsed with the urgency of life and death and sat at the crossroad of a nation at war with itself. That history lingers most clearly at the Mound City National Cemetery, just beyond the edge of town. I wasn’t expecting to find it, and I certainly wasn’t expecting the names etched into some of the stones. Two men in particular stood out, John Basil Turchin and Alexander Bielaski. Both born in the Russian Empire. Both connected to Abraham Lincoln. Both now buried here, far from where they began. John Basil Turchin (born Ivan Turchaninov) had once been a colonel in the Russian Imperial Army. He fought in the Crimean War before immigrating to the United States in 1856. When the Civil War broke out, he offered his experience to the Union cause with fierce conviction. His military background and abolitionist ideals caught Lincoln’s attention, and he was appointed a brigadier general, becoming the only Russian born general to serve in the Union Army. He died in 1901 and was laid to rest here, among the soldiers he once led, and some that he fought against.

Detailed fact-check analysis of: Built on ancient Native American mounds near the meeting point of where the Ohio and Mississippi Rivers clash, the town sits at a natural crossroads. During the Civil War, that geography turned it into a vital Union stronghold. Mound City became home to one of the largest military hospitals in the West and served as a major naval station. Soldiers from both sides passed through some to recover, many not. It may be quiet now, but this place once pulsed with the urgency of life and death and sat at the crossroad of a nation at war with itself. That history lingers most clearly at the Mound City National Cemetery, just beyond the edge of town. I wasn’t expecting to find it, and I certainly wasn’t expecting the names etched into some of the stones. Two men in particular stood out, John Basil Turchin and Alexander Bielaski. Both born in the Russian Empire. Both connected to Abraham Lincoln. Both now buried here, far from where they began. John Basil Turchin (born Ivan Turchaninov) had once been a colonel in the Russian Imperial Army. He fought in the Crimean War before immigrating to the United States in 1856. When the Civil War broke out, he offered his experience to the Union cause with fierce conviction. His military background and abolitionist ideals caught Lincoln’s attention, and he was appointed a brigadier general, becoming the only Russian born general to serve in the Union Army. He died in 1901 and was laid to rest here, among the soldiers he once led, and some that he fought against.

Jul 30, 2025
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F., et al. (2023). The lived experience of meltdowns for autistic adults. Autism, 27(7), 1787–1799. https://doi.org/10.1177/13623613221145783 Malik, J., et al. (2019). Emotional flooding in response to negative affect in romantic relationships. Journal of Couple & Relationship Therapy, 18(4), 327–349. https://doi.org/10.1080/15332691.2019.1641188 Gottman Institute. (2024, March 4). Making sure emotional flooding doesn’t capsize your relationship. Retrieved from https://www.gottman.com/blog/making-sure-emotional-flooding-doesnt-capsize-your-relationship/

Detailed fact-check analysis of: Autistic Non-Verbal Episodes in Marriage: Why Words Vanish Sometimes and What to Do About It Neurodiverse Couples Tuesday, august 12, 2025. Here’s the scene: You’re in the middle of a conversation with your spouse. Maybe the topic is small (“Did you pay the water bill?”) or monumental (“Are we happy?”). And then—without warning—your autistic partner’s voice disappears. No yelling, no slammed doors. Just… gone. You’re left holding the conversational steering wheel while they’ve quietly climbed into the trunk. If you’ve never lived with high-functioning autism, this can be tragically misconstrued as stonewalling or contempt. It isn’t. It’s just neurology pulling the emergency brake. Why This Happens: The Science Without the Lab Coat Smell For autistic adults, losing speech under stress is often a shutdown—a form of nervous system overload that knocks language production offline. Think of it like your phone freezing: all the apps are still there, but none of them open when you tap. Research calls this autistic burnout when it happens in a longer, chronic cycle—linked to masking (Hull et al., 2017; Raymaker et al., 2020). Masking is the art of “performing normal” so well that non-autistic people think you’re fine. The issue is that it eats through your energy reserves like a car idling in traffic with the A/C on full blast (Mantzalas et al., 2022). Eventually, one hard conversation can tip you from functional to frozen. And here’s where couples therapy meets neuroscience: physiological flooding—the body’s fight/flight/freeze switch—is a known relationship killer (Malik et al., 2019; Gottman Institute, 2024). In other words, for some autistic partners, flooding may tend to show up sooner, last longer, and is more likely to pull the plug on speech entirely. The Danger Loop in Marriage Autistic partner goes non-verbal — brain says “nope.” Non-autistic partner reads it as avoidance — brain says “attack.” Pressure increases — “Just say something.” Shutdown deepens — and now you’ve both lost. Do that a few hundred times and you’ll start conflating a physiological response into a moral failing. That’s the real marriage-killer. The Protocol: Three Phases, Zero Guesswork This is where we get practical. You can’t “love away” a temporary shutdown, but you can stop it from turning into World War III. Before: Build the Net Name the state. Agree on a phrase or signal ( I call this a couple code)—such as “words offline,” “shutdown,” a hand over the heart. The point is to make the invisible visible. The Shutdown Card. A literal card that says: I can’t speak right now. Please lower lights, reduce sound, give me X minutes. I promise I will circle back. The Pause Rule. Require a minimum of 20 minutes before resuming any tough talk. Autistic partner may need 90+. Agree ahead of time. Downgrade Kit. the usual gear; earplugs, soft light, weighted blanket, fidget, a quiet room. You know, human decency in object form. Reduce Daily Load. Avoid heavy talks right after work or big social events. Chronic overload makes a nervous shutdown more probable. During: Do Less, Better Autistic Partner: Give the signal. Exit stimulation. Switch channels if possible (text, notes app, yes/no cards). Send a short pre-written message: “Safe, can’t talk, back at 8:15.” Non-Autistic Partner: Acknowledge once—“Got it, I’m with you.” Hold the pause boundary. Lower stimuli. Go regulate your own nervous system—walk, journal, pet the dog. Don’t rehearse comebacks. Both: Avoid sarcasm, interrogation, ultimatums. Nothing lengthens a shutdown like moral outrage. After: Close the Loop Check in: “Are you ready to talk, or should we start in text?” Debrief: Identify triggers and what helped. Solve the actual problem. 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