Fact Check: "CRISPR can cut away the extra chromosome causing Down syndrome."
What We Know
Down syndrome, or trisomy 21, results from the presence of an extra copy of chromosome 21, leading to various developmental and cognitive challenges. Recent advancements in gene editing, particularly using the CRISPR-Cas9 system, have shown promise in addressing this condition. A study published in the Proceedings of the National Academy of Sciences demonstrated that researchers successfully employed CRISPR to eliminate the surplus chromosome in human cells derived from individuals with Down syndrome. This method, termed allele-specific multiple chromosome cleavage, was effective in both induced pluripotent stem cells and fibroblasts, indicating its potential for broader applications (source-1, source-4).
The researchers found that removing the extra chromosome not only normalized gene expression but also improved cell viability and function. The study highlighted that the technique could potentially correct the genetic imbalance that causes the symptoms associated with Down syndrome (source-2, source-6).
Analysis
The claim that CRISPR can cut away the extra chromosome causing Down syndrome is supported by credible scientific research. The study led by Ryotaro Hashizume and colleagues utilized CRISPR-Cas9 to specifically target and remove the third copy of chromosome 21 from trisomic cells. This approach is significant because it represents a shift from traditional gene editing, which typically makes small modifications, to a method capable of removing entire chromosomes (source-3, source-5).
The reliability of the sources is high, as they are published in peer-reviewed journals and involve reputable researchers in the field. However, it is essential to note that while these findings are promising, the technique is still in the experimental stage and not yet ready for clinical application. The researchers are working on refining the method to minimize potential off-target effects, which is a common concern with CRISPR technology (source-7, source-8).
Conclusion
The claim that "CRISPR can cut away the extra chromosome causing Down syndrome" is True. The evidence from recent studies indicates that CRISPR-Cas9 can effectively target and remove the extra chromosome 21 in cells affected by Down syndrome, leading to normalization of gene expression and improved cellular function. While the research is still in its early stages, it opens up exciting possibilities for future therapies aimed at addressing the genetic basis of Down syndrome.
Sources
- Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells. PubMed
- CRISPR used to remove extra chromosomes in Down syndrome and restore cell function. Earth.com
- Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9. PNAS Nexus
- Using CRISPR to remove extra chromosomes in Down syndrome. EurekAlert
- Unlocking New Possibilities: Gene Editing and Down Syndrome. DS Achieves
- CRISPR Successfully Removes Extra Chromosome 21. Conexiant
- Innovative Approach Developed for Removing Extra Chromosome 21 in Cells from Individuals with Down Syndrome. Mie University
- CRISPR Snips Away Extra Chromosomes, Offering New Hope for Down Syndrome Treatment. SciTechDaily
