Fact Check: "Benadryl can cause weight gain as a side effect."
What We Know
Benadryl, a brand name for the antihistamine diphenhydramine, is commonly used to treat allergy symptoms, but it has also been associated with weight gain. Research indicates that H1 receptor antagonists, including Benadryl, can stimulate appetite and lead to increased body weight. A study published in the Journal of Obesity analyzed data from the National Health and Nutrition Examination Survey (NHANES) and found that adults using prescription H1 antihistamines had significantly higher body mass index (BMI), waist circumference, and insulin levels compared to non-users (source-1).
Furthermore, an article from the Obesity Medicine Association notes that while occasional use of Benadryl may not lead to significant weight gain, chronic use can interfere with weight management (source-2). Other sources corroborate that antihistamines can lead to increased appetite and weight gain due to their mechanism of action on histamine receptors (source-3, source-5).
Analysis
The evidence supporting the claim that Benadryl can cause weight gain is substantial. The 2010 study from Yale University indicates a clear correlation between the use of prescription H1 antihistamines and obesity, with users showing a higher average weight and BMI compared to matched controls (source-1). This study is particularly credible as it utilizes a robust dataset (NHANES) that is well-regarded in public health research.
However, it is important to note that the study primarily focused on prescription antihistamines, and while Benadryl is available over-the-counter, its effects are likely similar due to its classification as an H1 antagonist. The potential for weight gain is further supported by clinical observations and other studies that indicate increased appetite as a side effect of antihistamines (source-2, source-6).
Critically, some sources caution that while there is an association, causation cannot be definitively established from cross-sectional studies alone (source-2, source-7). This means that while antihistamines like Benadryl can contribute to weight gain, individual factors such as pre-existing weight, lifestyle, and dietary habits also play significant roles.
Conclusion
The claim that "Benadryl can cause weight gain as a side effect" is True. Multiple studies and expert opinions indicate a clear association between the use of H1 antihistamines, including Benadryl, and weight gain. The mechanism by which these medications may increase appetite and promote weight gain is well-documented, making it reasonable to conclude that chronic use of Benadryl could lead to weight gain in some individuals.
Sources
- Association of prescription H1 antihistamine use with obesity: Results from the National Health and Nutrition Examination Survey. Read More
- Antihistamines and Weight Gain. Read More
- Can Antihistamines Like Zyrtec Cause Weight Gain? Read More
- Benadryl can make me fat?! Common medications that cause weight gain. Read More
- Antihistamines and weight gain. Read More
- Do Antihistamines Cause Weight Gain? Read More
- Is Antihistamine Use Making Me Gain Weight? Read More
- Is your allergy medicine making you gain weight? Read More
