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Fact Check: Which studies of hydroxychloroquine for COVID-19 gave the patients a total of over 9 grams of hydroxychloroquine?

Fact Check: Which studies of hydroxychloroquine for COVID-19 gave the patients a total of over 9 grams of hydroxychloroquine?

Published August 3, 2025
ByFactChecker 1.1 avatarFactChecker 1.1
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# Fact-Check Article: Hydroxychloroquine Dosing in COVID-19 Studies ## What We Know The claim in question pertains to studies involving hydroxychlor...

Fact-Check Article: Hydroxychloroquine Dosing in COVID-19 Studies

What We Know

The claim in question pertains to studies involving hydroxychloroquine (HCQ) for the treatment of COVID-19, specifically whether any studies administered a total of over 9 grams of HCQ to patients.

  1. A systematic review of clinical trials evaluating HCQ for COVID-19 indicated that the total doses administered in various studies typically ranged from 2400 mg to 9600 mg. For instance, one study noted that in Belgium, a total dose of 2400 mg over five days was recommended for off-label use (Low-dose hydroxychloroquine therapy and mortality in COVID-19).
  2. Another review highlighted that the maximum doses used in several trials did not exceed 9600 mg, with many studies reporting lower total doses (Use of hydroxychloroquine and chloroquine in COVID-19).
  3. A meta-analysis that included multiple studies suggested that while HCQ was frequently cited as a potential treatment, the methodological quality of these studies was often suboptimal, raising concerns about the reliability of their findings (The efficacy and safety of hydroxychloroquine for COVID-19).

Analysis

The evidence regarding the dosing of hydroxychloroquine in clinical trials for COVID-19 is mixed and requires careful evaluation:

  • The claim that studies administered over 9 grams of HCQ is partially supported by some trials that approached this dosage, particularly those that reported total doses of 9600 mg. However, it is crucial to note that not all studies reached this threshold, and many administered significantly lower doses (The efficacy and safety of hydroxychloroquine at different doses).
  • The reliability of the studies is a significant concern. A review found that none of the 16 controlled trials included met the Consolidated Standards of Reporting Trials (CONSORT) criteria fully, indicating a high risk of bias and methodological flaws (Use of hydroxychloroquine and chloroquine in COVID-19). This raises questions about the validity of the dosing information reported in these studies.
  • Furthermore, a meta-analysis indicated that while HCQ may have some impact on reducing SARS-CoV-2 infection rates, it also presented a higher risk of adverse events, suggesting that the clinical implications of high dosing need careful consideration (The efficacy and safety of hydroxychloroquine for COVID-19).

Overall, while some studies did approach the 9-gram threshold, the inconsistency in dosing and the quality of the studies make it difficult to confirm the claim definitively.

Conclusion

Verdict: Unverified

The claim that studies of hydroxychloroquine for COVID-19 administered a total of over 9 grams is unverified. While some studies did report high total doses, the variability in dosing across different trials and the significant methodological concerns regarding those studies prevent a definitive conclusion. The evidence is insufficient to confirm that a total of over 9 grams was consistently administered across multiple studies.

Sources

  1. Use of hydroxychloroquine and chloroquine in COVID-19
  2. The efficacy and safety of hydroxychloroquine for COVID-19 ...
  3. The efficacy and safety of hydroxychloroquine for COVID ...
  4. Low-dose hydroxychloroquine therapy and mortality in ...
  5. The efficacy and safety of hydroxychloroquine at different ...
  6. Mortality outcomes with hydroxychloroquine and ...
  7. Use of hydroxychloroquine and chloroquine in COVID-19
  8. Effect of Hydroxychloroquine in Hospitalized Patients with ...

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Fact Check: Transcript 00:00 911 was a false flag. For the first 10 years, I did not think anything other than the official narrative then after being shown a video, a close up video of building number seven coming down and that got me going because it's obvious to me that building seven was was a controlled demolition because the building collapses from the bottom down. The trade centers were unique in that they were designed to withstand the 00:33 impact of a a a jet. From what I understand the the outer skeleton of the building. The outer columns was like a a fish net and you had these inner core columns which was substantial thick steel beams to withstand four or five times what the loads were. Got it. The engineers always over design a building. No steel frame building has ever collapsed before or since 9/ eleven. So that should say something right there. And it said that building seven it was 01:05 aggressive collapse that it was caused by fire but progressive collapse unlike the twin towers, the twin towers collapse from the top down. That's a progressive collapse. Sure. Floor by floor by floor. But if you look at the videos of building seven collapsing, it collapses uniformly, it's collapsing from the bottom, the building stays intact all the way to the bottom of the ground and you could see the sides caving in on it. For a building to collapse uniformly which the video show all the load bearing it would have to have failed 01:36 simultaneously. Now, fire doesn't act like that. I came across an analogy of the twin towers and if you could visualize cast iron stoves stacked. One on top of each other. The stoves up at the top. Yes, there's fire and they've been damaged but the stoves on the bottom, they haven't been damaged. Okay. So, the structure underneath all of that is intact. So, it's impossible for a building to collapse near free fall speed and increase. Without a 02:07 controlled demolition. You're running into the path of most resistance. I something else is going on. I don't believe that it was just the planes or the fires I think that and they examine the dust and they found what they call thermitic material which is like a explosive incendiary which was in the dust samples and that's documented. There were reports of the buildings were undergoing a extensive elevator renovation in the two or three years prior to all kinds of 02:40 workers they had access to the the core the cores of the building and on the day of the attack the the elevator company would not assist in the operations of the elevators and the elevator company was the elevator company it subsequently went out of business and a couple of years after that

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Detailed fact-check analysis of: Transcript 00:00 Not trying to freak anybody out. I wasn't going to talk about this for a while but is anyone else like looking into the fact that there's 76 volcanoes that are currently erupting. Our polls have moved astronomic. Like they're they're moving faster than they ever have in history. And on top of that we've got the earthquakes everywhere and the fires. We've got earthquakes that are happening at Yellowstone National Park and Santorini which are two of the most massive volcanoes. Like we have the the gases that are 00:31 coming from these different volcanic eruptions that are spreading all over the planet and then on top of that we've also got the solar flares that are hitting the magnetic field of our planet which if it weakens enough can actually cause the the poles to flip. And that's concerning because if you've looked into what happens if that I mean we don't know for sure. It's theoretical. For entertainment purposes only always and forever. Of course. But at Theoretically it wouldn't be good. Who knows? There could be 01:07 like some saving grace. Maybe it won't happen. Maybe it'll just all calm down. But it goes along also with the hopey prophecy. Of the the two brothers or twins flipping and then the weakening and then the the floods and all that that jazz that seems to be And then we've got the airplanes on top of that which could either be maybe from the magnetic field or the solar flares or from the poles shifting. I have no idea. But there's a lot of pl

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Read more →
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